The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Ask your healthcare provider what your test results mean for you. Your test results may not mean you have a problem. Test results may vary depending on your age, gender, health history, the method used for the test, and other things. – Zinc deficiency (cofactor BHMT) WHAT DOES IT MEAN IF YOUR DIMETHYLGLYCINE ( DMG) RESULT IS TOO HIGH?
WHAT DOES IT MEAN IF YOUR DIMETHYLGLYCINE ( DMG) RESULT IS TOO LOW? Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. – da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. Townsend Letter for Doctors and Patients. Recent findings on N, N-dimethylglycine (DMG): a nutrient for the new millennium. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Intake and supplementation with DMG plays an important role in keeping Hcy levels stable and providing methyl donors. īecause it contains two methyl groups for donation, therapeutic interventions with DMG have been successful in many conditions including autism, hyperlipidemia, chronic fatigue syndrome, systemic lupus erythematosus, and cardiovascular disease. The molecule was first reported in 1943, and is a naturally occurring intermediate metabolite in plant and animal cells (Reference Tonda and Hart 1, Reference Currell, Ayed and Dziedzic 2). It was used in the Soviet Union in the 1960’s as part of a formula to benefit athletic performance. Dietary sources include cereal grains, seeds, beans and liver. N,N-dimethylglycine (DMG), a methylated derivative of the amino acid glycine with the chemical formula (CH 3) 2 NCH 2 COOH, has been used for various human and animal applications. Ĭlinically, DMG elevations may indicate an increase in activity of the BHMT “salvage-pathway.” Therefore, high DMG may reflect the need for additional folate, vitamin B12, and zinc.ĭMG has been marketed safely as a nutritional supplement since 1974. Elevations in DMG act as a negative feedback by inhibiting this enzymatic conversion.
This methyl donation is mediated by the enzyme betaine homocysteine methyltransferase (BHMT). The amino acid derivative dimethylglycine (DMG) is produced when betaine (trimethylglycine) donates a methyl group to homocysteine for re-methylation back to methionine.
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